WebDec 29, 2024 · We report important molecular insights into the dual-catalytic asymmetric allylic amination involving a combination of Pd(PPh 3) 4 and a double axially chiral phosphoric acid catalyst as the source of chirality (Scheme 1(a)). The discussions are organized into five sections; (a) nature of the active catalyst, (b) overview of the catalytic …

Chiral organophosphates as ligands in asymmetric metal catalysis ...

WebJan 11, 2006 · The development of a new chiral phosphoric acid catalyst has provided a convenient strategy for the enantioselective construction of protected primary amines and provided a highly stereoselective method for the reductive amination of heterocyclic amines. A diverse spectrum of ketone and amine substrates can be accommodated in high yield … WebMar 31, 2024 · Utilizing chiral phosphoric acid as the catalyst, these axially chiral styrenes were prepared in good yields (up to 96%) and excellent stereoselectivity (up to … healthecrm

Synthesis of a C2-Symmetric Chiral Borinic Acid and Its …

WebThe reaction was enabled by synergistic palladium and chiral phosphoric acid catalysis and produced chiral cis-1,3-disubstituted 1,3-dihydroisobenzofurans with a selective factor of up to 60.9 and ... WebThe reaction was carried out in the presence of chiral phosphoric acid catalyst 127 and the oxidant DDQ from the start, precluding the isolation of the non-aromatic intermediate. However, for three examples, the reaction was carried out in a sequential fashion with treatment by DDQ after the isolation of the intermediate 129 . WebDec 3, 2024 · Through the combined action of palladium catalysts and chiral phosphoric acids (CPAs) a variety of catalytic asymmetric reactions have been realized during the past decade, including allylation, alkene … gong cha north lakes