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WebPatient demographic characteristics found to influence the pharmacokinetics of duloxetine include sex, smoking status, age, ethnicity, cytochrome P450 (CYP) 2D6 genotype, hepatic function and renal function. Of these, only impaired hepatic function or severely impaired renal function warrant specific warnings or dose recommendations. WebRenal failure, renal impairment Avoid use of duloxetine in patients with severe renal impairment (eGFR less than 30 mL/minute/1.73 m2). Increased plasma concentrations of duloxetine, and especially of its metabolites, occur in patients with end-stage renal disease and renal failure. only snake in ireland ac valhalla
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