WebMar 9, 2024 · RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway. [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability]. RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR … WebDiscovery. The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. In 2024, the same three …
RBM38 RNA binding motif protein 38 [ (human)] - National Center …
WebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl hydroxylase and rapidly degraded through the VHL-mediated proteasomal pathway . Once ... RBM38 prevents eIF4E from binding HIF1α transcript (A) ... WebJan 1, 2015 · Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, consists of HIF1α and HIF1β and is necessary for cell growth and survival under a hypoxic … highpass
HIF1α 5′ and 3′UTRs are necessary and sufficient for …
WebDec 15, 2014 · In this study, Rbm38- and p53-deficient mice models were used to characterize the biological function of Rbm38 and the role of the p53-Rbm38 loop in aging and tumor suppression. We showed that Rbm38 plays an instrumental role in aging, normal hematopoiesis, and tumor suppression. WebDownload scientific diagram RBM38 directly binds to HIF1α 5′ and 3′ UTRs. (A) Whole cell lysates from H1299 cells were collected and immunoprecipitated with anti-RBM38 … WebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to … small savings schemes in india