Read across approach toxicology
WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has been used in a relatively specialist context implying “accepted” structural similarity, particularly within well-defined chemical classes. WebRead-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case …
Read across approach toxicology
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WebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each … WebApr 30, 2024 · defines grouping of substances and read-across approach as: “ Substances whose physicochemical, toxicological and ecotoxicological properties are likely to be …
Weband read across approach. Case Studies – Examples of NAMs Prediction of a 90 day Repeated Dose Toxicity Study . for 2-Ethylbuturic acid using a . read-across approach to other branched carboxylic acids. ... (NAM) for regulatory toxicology. ALTEX. 2024 Apr 30. doi: 10.14573/altex.1912181. WebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ...
Webread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has …
WebComputational Toxicology. Background & definitions • Read-across describes one of the data gap filling techniques used within analogue and category approaches • “Analogue approach” refers to grouping based on a very limited number of chemicals (e.g. target substance) + source substance) • “Category approach” is used when grouping ...
WebJan 1, 2024 · These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety … flushable wipes clogging nj sewerWeba National Center for Computational Toxicology (NCCT), ... any read-across approach should be broadly based in scope or lim-ited to a specific endpoint. Patlewicz et al. [39,40] discussed the ... flushable wipes cloggedWebComputational Toxicology 3 Definitions: Read-across • Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. • A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. • green fighting fishWebMar 10, 2024 · In read-across, available data on chemical structural analogues are used to predict the toxicity potential of the data-poor chemical. This approach has long been recognized by regulatory agencies and used by industry to evaluate the hazards of chemicals for which there are limited direct data. flushable wipes at costcoWebRead-across describes one of the techniques for filling data gaps in either the analogue or category approaches i.e. not to be confused with the “analogue approach” – “Analogue … flushable wet wipes sewageWebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ... flushable wipes clogging sewage systems wgnWebOct 1, 2024 · A workshop on the “Read-across: Principle, case study and its potential regulatory application in China”, organized by the Chemical Risk Assessment Specialty … flushable wipes and the sewer line